Because of the abuse of antibiotics, there are many side effect appeared:
1. More and more Drug resistant bacteria, such as Common bacteria like salmonella, E. coli and Methicillin-resistant Staphylococcus aureus (MRSA), threatening our ability to treat illness and disease in humans
2. Drug residues harmful to human health
3. Kidney, liver toxicity effect animal health growth
4. Break micro-ecological balance of body
5. Because of poor resistance and immunity, animals susceptible to various diseases, and various viral diseases cause death
The European Union, Korea, USA, Canada have prohibited the antibiotics use in feed.
China and Brazil have prohibited the use of colistin sulfate in feed
Decision of the four session of the twelve National People's congress:
1. Prohibit use lomefloxacin, pefloxacin, norfloxacin and ofloxacin for food animal from 31st,Dec 2016;
2. Intends to prohibit colistin sulfate use as growth promoter, recently are comments to the community, is expected to be completed by the end of 2016;
3. Encourage and support the development of new veterinary drugs, such as microbial, antimicrobial peptides, herbal extracts, to improve the level of animal health, reduce the use of antibiotics as growth promoter and the use of veterinary drugs
With the forbidden of colistin sulfate, II antibiotics and olaquindox, the feed additives to against the gram-negative bacterial almost none available, how to solve the weaning piglets diarrhea problem is the top priority of feed companies, seeking effective antibiotics alternatives is extremely urgent and important.
Microbial lysozyme is the best choice, lysozyme is a protein which could dissolves bacteria, named lysozyme (muramidase).
Rumor has it that in 1921, a droplet from Fleming’s nose (who was nursing a cold while working in his lab) accidentally fell into one of the Petri dishes containing microorganisms. Noticing the reaction of the bacteria to the fluid, Fleming deduced that it must have contained a “remarkable bacteriolytic element”, and so he set out to isolate it.
That same year he announced that this element, named LYSOZYME because of its lysing antibacterial action.
Lysozyme is divided into different types according to the source, there are animal & human lysozyme, plant lysozyme, microbes lysozyme and egg-white lysozyme. Now, the most common lysozyme in the market is egg white lysozyme which is extracted from eggs, it is widely used in food industrial as preservative. Microbial lysozyme are fermented lysozyme.
Microbial lysozyme has very good bactericidal effect on gram-positive bacteria and gram-negative bacteria in a low concentration, it could be verified by tests.
Zhejiang Aegis Biotech Co., Ltd. is professionally engaged in R&D and produce Microbial Lysozyme for more than 15 years. We are the Chinese largest microbial lysozyme production and export enterprises, also is the National Industry Standard-setting company of lysozyme.
Brief of Aegis lysozyme
Microbial lysozyme could replace antibiotics use in feed completely, could also use with antibiotics to enhance its effect by 2-8 times, could solve the drug-resistance problem caused by abuse of antibiotics. Microbial lysozyme is a kind of microbial source one which is fermentated through microbe (pichia pastoris) , using of genetic engineering & technology. It has the function of broad-spectrum antibacterial, anti-inflammatory, anti-virus, enhancing the immunity and repairing injured body tissue, promoting the proliferation of useful bacteria and so on.
Aegis lysozyme properties
1.Broad-spectrum, the result of prevention & treatment is significant, has enough power to kill the antibiotic-resistant strains, the control rates of bacterial disease come to 85-95%, relapse rates is below 5%. Compared with egg-white lysozyme, microbial lysozyme anti-bacteria range is much broader and the effect is much better.
2.Ensure the micro ecological environment of the animal intestine maintained at the optimum status, enhance the body digestibility & absorption, increase FI, ADG & FCR significantly.
3.No antibiotic-resistance, can be used in long term without rotation of drug, if combined with antibiotics its results can be synergetic to 2-8 times.
4.Promote the recovery of inner membrane injured in digestible tract, enhance the protection of inner membrane in digestible tract (can eliminate the side-effect of ZnO; and synergy with coccidiostats), benefit the recovery of birth canal and trauma.
5.Of targeting function, gather to target organ, penetrate the barrier of reproductive system, enhance the control effect to the stubborn disease. The effect is much better especially applied for breeding livestock & poultry.
6.Safety, efficiency, green, environment protection---------people of industry is striving to pursue, which is also the security of exported enterprise.
Application
Microbial lysozyme application in Food, animal husbandry, daily chemical industrial, and poultry, pig, Ruminant, Aquaculture, Fur animal.
Using Case Sharing:
1. Big pig farm in Zhejiang province
(1）Program:
I. Control group was fed by normal basal diet, creep feed (DBN S100), piglet feed (40% of the Guangzhou 8V premix)
II. The test group added microbial lysozyme 10% into the free-antibiotics ration according to 1 kg/Ton ( microbial lysozyme supplied by Zhejiang Aegis Biotech Co. Ltd.)
III. Experimental pigs: three-crossbred Pigs, the average age was 26 days.
(2) Result of creep feed. Test period: 8 days
ADFI increased 49.35g
(3) Result of nursery pig. Test period: 19 days
ADW increased 24g
ADFI increased 22.4g
FCR decreased 0.064
ADW = average daily weight gain
ADFI = average daily feed intake
FCR = Feed/Meat ratio
2. A leading poultry feed factory - test on broiler
Control group 54060 broilers: Without AGP (Negative control) + Enramycin 125 g/ton feed
Test Group 51000 broilers: NC+Enramycin125g/ton feed+lysozyme 100 g/ton feed
Test Results:
Parameters
|
Without lysome
|
With lysozyme
|
Total bird
|
54060
|
51000
|
Mortality
|
2840
|
2190
|
Mortality %
|
5.253422124
|
4.294117647
|
Liveability %
|
94.74657788
|
95.70588235
|
Total weight
|
137810
|
127095
|
Avg. Wt
|
2.6905
|
2.6035
|
TOTAL Feed intake
|
4532
|
4055
|
FI (Kg)
|
226600
|
202750
|
FCR
|
1.644292867
|
1.595263386
|
Avg. age
|
43.075
|
41.44
|
3.
Contact
Ms.Crystal Yu
Zhejiang Aegis Biotech Co., Ltd
Add: No.1075, Danfeng Road, Binjiang District of Hangzhou. 310051,China
Tel: +86 571-87692606 Fax: +86 571-85334696
Mob/WhatsApp/Viber : +86 18920540763 Email: crystal@aegisgroup.cn
